Endocrine Disorders & Skin Disease

Healthy skin and a normal hair coat are a result of many factors, both internal and external. The body contains several glands, which secrete hormones into the bloodstream. These glands and their hormones are called the endocrine system. The hormones are vital to normal skin and hair coat production and are necessary for the regulation of other body functions.

A common cause of skin disease is a failure of an endocrine organ to secrete the proper amount of its hormone. This usually results in some degree of hair loss and abnormal skin quality. Depending on the hormone involved, there may be other subtle changes noted in the pet’s history or found on the physical exam. This information may help us decide which organ is most likely involved and thus direct our testing. Hormonal disorders usually carry a good prognosis. Some are treated with lifelong medication, while others are cured surgically.

The following is a brief summary of the endocrine disorders which may cause skin disease in the dog:

Cause: Insufficient thyroid hormone production
Signs: Hair loss, dark skin, dandruff, overweight, lethargy, poor hair coat, recurrent infections
Tests: CBC, chemistry panel, thyroid panel, skin biopsy
Treatment: Thyroid (pills) supplement for life

Cushing’s Disease
Cause: Excessive cortisone production by the adrenal gland or a pituitary (brain) problem
Signs: Hair loss, thin skin, muscle wasting, weakness, excessive water intake, panting, pot-
belly, recurrent infections, poor hair coat
Tests: CBC, chemistry panel, urinalysis, urine culture, skin biopsy, adrenal function tests,
abdominal ultrasound
Treatment: Medication (lifelong) or surgery depending on whether the problem is the adrenal or
the pituitary

Sex Hormone Imbalance
Cause: Abnormal estrogen, progesterone or testosterone levels
Signs: Hair loss, poor hair coat, change in coat color
Tests: Skin biopsy, sex hormone blood levels
Treatment: Surgical (spaying or neutering) or hormone replacement

Seasonal Flank Alopecia
Cause: Unknown at this time, but it is believed to be related to photoperiod (length of day)
Signs: Hair loss especially in the flank and lateral trunk area, darkening of the skin, scaling
Tests: Skin biopsy
Treatment: Melatonin (?)

Please note that all the signs may not be present. Also, these disorders can mimic one another, so that it may be necessary to test for multiple endocrine disorders.

For more information on this subject, speak to the veterinarian who is treating your pet.

© BluePearl Veterinary Partners 2012